Protein Capture Science Accelerates Medical Therapies by Sarah Risch, Rev1 Ventures

Extraordinary Mary  J. Grinstead interview with Drs. David Wood and Izabela Gierach.

Enjoy!

Start-up Challenge 2021 (EU) by European Economic Congress (Online & In Person)

Once again Protein Capture Science was chosen as one of the most interesting 100 startups across the world out of firms competing during Start-up Challenge organized as a part of European Tech and Start-up Days & European Economic Congress conference, September 20-22, 2021, Katowice, Poland.

More about the meeting:

"A meeting of global brand creators, business visionaries and explorers. A space integrating the circles of young entrepreneurs with experts, presidents of large companies, investors and successful businesspeople from various industries, who are present at the European Economic Congress in Katowice – the largest business meeting in Central Europe." 

Protein Capture Science Seeks to Accelerate Biomedical Research 

By Ashley Baig, Rev1 Ventures

Great interview with Dr. David Wood and Dr. Izabela Gierach, the co-founders of Protein Capture Science. 

Start-up Challenge 2020 (EU) by European Economic Congress

Protein Capture Science was chosen as one of the most interesting 100 startups across the world out of 250 firms competing during Start-up Challenge organized as a part of European Tech and Start-up Days & European Economic Congress conference, Katowice, Poland, September 3-4, 2020.

More about the meeting:

"A meeting of global brand creators, business visionaries and explorers. A space integrating the circles of young entrepreneurs with experts, presidents of large companies, investors and successful businesspeople from various industries, who are present at the European Economic Congress in Katowice – the largest business meeting in Central Europe." 

The Chain: Protein Engineering Podcast, 2020

David Wood, Developing a Novel Self-Cleaving Tag Technology while Learning From Both Success and Failure

OSU Media, February 2020

Professor’s startup tackles biopharmaceutical manufacturing problem, February 21, 2020.

BioProcess International US West 2025 in San Diego, CA 

Dr. David Wood presentation is on March 21st, 2025 from 11:00 a.m. to 11:30 a.m. (PT), San Diego Convention Center, San Diego, CA, USA

Session: Manufacturing Strategy & Digital Transformation

Title: Strategies for Validating Affinity Tag Removal in GMP Bioprocessing

Great News! Dr. David Wood is presenting at the AICHE 2024 Meeting in San Diego, CA. 

Title of the presentation: 

Self-Removing Affinity Tags to Streamline Preclinical and Clinical Manufacturing Under a Single Purification Platform (#611a in the meeting agenda)

Date: October 30th, 2024

Time: 3:30 PM - 4:00 PM (PT)

Location: Room 28A (Upper Level, San Diego Convention Center)

The Bioprocessing Summit, Boston August 21-22, 2024

Advances in Purification and Recovery Optimizing Downstream Efficiency

David Wood presents on August 22, 2024  at 8:30 a.m:

"Process Validation of a Self-Removing Affinity Tag for cGMP Biologics Manufacturing"

National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) National Meeting, Washington, DC, 25th-27th June 2024

Meet with us:

- Lightning Talk (8:30 a.m. - 10:10 a.m. session, Tuesday, June 25)

- Poster Presentation (Tuesday, June 25, 6:30 p.m.)

Izabela Gierach & David Wood

present "Validating Tag

Removal for the Adoption of Self-Removing Affinity Tag Technology in GMP Biopharmaceutical Manufacturing"

Co-authors: David Wood, Izabela Gierach, Sophia Mayone, Nathan Moody, Sabat Gonzalez-Serrano

- Lunch:

Tuesday 12:30 p.m.

Wednesday 12:00 p.m.

Thursday 12:30 p.m.

20th Recovery of Biological Products

Sunriver Resort, OR June 2-7, 2024

Dr. David Wood presents:

“Cleavable affinity tags can revolutionize biologics manufacturing –  but how do we convince the FDA?”

Morning Session: 8:05 a.m. (PT) June 5, 2024

36th International Symposium on Preparative and Process Chromatography

Philadelphia, PA, USA   

May 28-31, 2024

David Wood is presenting

"Purification of Therapeutic Proteins Expressed in Mammalian Hosts Using a Self-removing Affinity Tag"

May 29, 9:20 a.m. EST

Session 1: Bioprocess

ROOM COMMONWEALTH BCD

Join the Session and Enjoy!

PEGS Conference, Boston, MA, May 14, 2024 (Online & In Person)

Dr. David Wood presents a presentation "Self-Removing Tandem Tags for Optimized Expression and Purification of Challenging Proteins"" at PEGS Meeting in Boston.

Focus of the Session: 

 Protein Production Tools

Dates & Location:

5:10 PM May 14 2024, Omni Boston Hotel at theSeaport, Contemporary Room, Boston, MA

The Festival of Biologics Conference, San Diego Convention Center, San Diego, California, 15th-17th April 2024

Conference Room: ROOM 4

4:50 p.m. - 5:10 p.m. (PT) 

April 16th,  2024 

Dr. David Wood is presenting: 

"Accelerating the development of non-classical mAb formats via a novel affinity approach"

• Self-removing affinity tag provides purified tagless proteins under a simple platform approach
• Affinity resin is designed for applications from research to manufacturing
• Robust capture and cleaving allows great latitude in designing process buffers
• Several case studies on non-mAb formats, including challenging proteins

Join us!

ACS Spring 2024, New Orleans,  LA March 17-2 2024

Izabela Gierach presents "Breaking the rules in tagless purification with iCapTag" (poster session)

March 19th 2024 

7:00 p.m. - 9:00 p.m.

New Orleans Ernest N. Morial Convention Center

New Orleans, Louisiana 

National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) National Meeting, Washington, DC, 27th-29th June 2023

Meet with us:

- Lightning Talk (Tuesday, June 27, 10:00 am)

- Company Poster Presentation (Tuesday, June 27, 3:45 p.m.)

Izabela Gierach & David Wood present "Biomanufacturing with the iCapTag™: a Novel Scalable & Tagless Protein Purification Platform"

- Lunch:

Tuesday 12:50 p.m.

Wednesday 11:45 a.m.

Thursday 12:00 p.m.

The Festival of Biologics Conference, Sheraton Hotel & Marina, San Diego, California, 20th-22nd March 2023

Main topics: Biologic drug discovery, development, manufacturing, pricing & market access.

Please see updated time & location:

12:00 p.m. - 12:20 p.m. (PT) 

March 21st,  2023 

Conference Room: Driftwood 1

Dr. David Wood is presenting: 

"Generalized Affinity Platforms for Simplified Downstream Processing: Applications in Biosimilars Manufacturing"

Join us!

2023 AMSUS Annual Meeting Healthcare Collaboration: Meeting the Challenges of Today and Tomorrow, Gaylord National Resort & Convention Center, National Harbor, MD

Meet Dr. Izabela Gierach presenting a poster between 4:30 p.m. - 5:30 p.m. (U.S. EST) on February 15th,  2023

Join all of us at Poster Exhibit Room/Location: Prince Georges Exhibit Hall A/B

Poster Title:

"The iCapTag a Novel Scalable Tagless Protein Purification Platform".

Co-authors: Drs. Izabela Gierach (presenter) & David Wood

Poster will be available to view between 11:00 a.m. - 5:30 p.m. on February 15th,  2023

Enjoy it!

PepTalk by Cambridge Healthtech Institute, Higher-Throughput Protein Production, San Diego, California, January 16 - 20, 2023

Join a session: Flexible and Agile Protein Purification and Characterization Workflows

January 19th, 2023 at 2:05 p.m. (U.S. Pacific Time), Room Location: Aqua Salon F

Session: Affinity Purification & Tags

Dr. David Wood is presenting "New Affinity Methods for Downstream GMP Processing: Custom Resins to Cleavable Tags".

January 20th, 2023 at 9:45 a.m. (U.S. Pacific Time), Room Location: Aqua Salon AB

Session: Flexible and Agile Protein Purification and Characterization Workflows

Dr. David Wood is presenting "Rapid Production of Highly Purified Tagless Proteins under a Simple Platform".

Join & enjoy it!

November 4th, 2022

"A Convenient Self-Removing Affinity Tag to Streamline Biopharmaceutical Discovery Through Manufacturing" by Dr. David Wood

Global Bioprocessing Summit in San Francisco, November 2nd-4th 2022

November 3rd, 2022 (Online)

"A Disruptive Approach to Streamline Research and Manufacturing

Under a Single Purification Platform" by Dr. David Wood & Dr. Izabela Gierach (guest speaker)

The 14th Annual Bioprocessing Summit in Boston, August 15-18, 2022

Chairperson's Opening Remarks: Dr. David W. Wood introduces exciting session about

"Challenging Formats and Emerging Modalities"

7:55 a.m. (EST), August 17th, 2022, Conference room: Back Bay C

Dr. David W. Wood presents 

"A Single Solution for Screening, Discovery, and Manufacturing of Biopharmaceuticals Based on a Self-Removing Affinity Tag"

10:00 a.m. (EST), August 18th, 2022, Conference room: Back Bay C

This is an invited presentation shown during "Advanced Technologies and Approaches" session. 

See you at the Bioprocessing Summit in Boston!

PEGS Conference, Boston, MA, May 2-6, 2022 (Online & In Person)

Dr. David Wood presents a presentation "Accelerating Protein Research to the Clinic through Self-Removing Affinity Tags" at PEGS Meeting in Boston.

Focus of the Session: 

Maximizing Protein Production Workflows; Optimizing Purification

Dates & Location:

May 5 - 6, 2022, Hynes Convention Center, Boston, MA

Drs. Izabela Gierach & David W. Wood were invited to ShowOHI/O 2022 to present iCapTag products.

Thank you everybody who visited us during ShowOHI/O 2022 in Columbus (April 8, 2022 6:00 PM - 8:30 PM). It was the Ohio State's annual tech innovation and entrepreneurship showcase.

The ShowOHI/O was hosted in person this year at the Longaberger Alumni House, Columbus, OH.

We had a lot of fun seeing everybody! Thanks for stopping by our booth!

BioProcess International U.S. West, San Diego, California, March 14-17, 2022

Hybrid Virtual & Online Meeting

Dr. David Wood presents "Development of a commercially viable self-cleaving tag technology for research and clinical manufacturing" at BioProcess International U.S. West (Hybrid Virtual & Online), San Diego Convention Center, San Diego, California, March 16, 2022 at 11:00 a.m. 

The Festival of Biologics Conference, World Antibody Congress, Marriott Marquis, San Diego, California, 9-11 March, 2022. Please see the updates below.

Join us!

2:40 p.m.-3:00 p.m. (U.S. Pacific Time), March 9th,  2022 

Dr. David Wood presents 

"A self-removing affinity tag for applications in research and biopharmaceutical manufacturing".

4:30 p.m.-5:10 p.m. (U.S. Pacific Time), March 9th,  2022 

Panel: Building Resiliency in Biosimilars Manufacturing

Dr. David Wood is a panelist with Julio Baez from University of California San Diego. 

PepTalk, Higher-Throughput Protein Production, San Diego, California, January 17 - 19, 2022 (check all of the exciting updates)

Dr. David Wood is presenting and he is also a panelist. See details below. Join & enjoy it!

January 17th, 2022,  3:00 p.m. (U.S. Pacific Time)

Join Dr. Wood during BuzZ Table 9: Future Platforms for Future Modalities

&

January 18th, 2022, 11:30 a.m. (U.S. Pacific Time) - updated time

Featured Presentation by Dr. Wood: 

"A Self-Cleaving Affinity Tag to Bridge Research and Manufacturing: Concept to Commercialization"

ACS Fall Meeting, Atlanta, GA,  August 22-26, 2021 (Online & In Person)

Izabela Gierach presents virtually a presentation "Bridging small and large scale manufacturing of non-mAb proteins via a single purification platform" at ACS Fall Meeting.

Time & Location: 

05:10pm - 05:30pm (U.S. EST)

August 25, 2021

Room: Zoom & Room 04

Full list of co-authors: Dr. Izabela Gierach (Presenter, Protein Capture Science); Jackelyn Galiardi (now Pfizer); Joseph Taris; Brian Marshall (now Eli Lilly); David Wood (Ohio State University)

American Chemical Society, Division of Biochemical Technology

Affinity 2021 Conference (virtual meeting)

Dr. David Wood will be speaking at the Affinity 2021 Conference.  Enjoy and see you there! June 22-24, 2021

Many Amazing Speakers Include:

• Prof. Alois Jungbauer, BOKU, Austria
• Prof. Mathias Uhlén, KTH, Sweden
• Profs. Dane Wittrup & Amy Keating, MIT, United States
• Profs. Jennifer Cochran & Sarah Heilshorn, Stanford University, United States
• Prof. Steven Cramer, Rensselaer Polytechnic Institute, United States
• Prof. David Baker, University of Washington, United States
• Prof. Rebecca Wade, Heidelberg Institute for Theoretical Studies, Germany
• Prof. Mibel Aguilar, Monash University, Australia
• Prof. Andreas Plückthun, University of Zurich, Germany

13th Annual Bioprocessing Summit (virtual & in-person)

David Wood, 13th Annual Bioprocessing Summit, Advances in Purification & Recovery, Boston, August 18-19, 2021.

3rd Annual Bioprocessing Virtual Conference, Labroots, 2021

David Wood, keynote speaker, 3rd Annual Bioprocessing Virtual Conference, an online-only event occurring on April 7, 2021.

Bioprocessing is the premier conference to discuss upstream and downstream processing, analytical development and quality, formulation and stability, cell and gene therapy production, and manufacturing. 

AICHE Meeting, 2021

Izabela Gierach and David Wood, present a poster "Bridging R&D and Manufacturing of Recombinant Proteins via a Self-Removing Tag", 7th International Conference on Accelerating Biopharmaceutical Development (AccBio 2021) Virtual Meeting, March 8-10, 2021.

Poster presentation, pre-recorded summary, and Q&A session after the poster session will happen on March 8th, 2021 from 12:10PM – 12:50PM Pacific Time.  If you have questions, please join us and enjoy the meeting.

Topic of the AccBio 2021 Meeting:

"Sessions will focus on Speed to Clinic, Speed to Launch, and End-to-End Supply Chain Resilience."

Virtual Workshops 2021

David Wood, Introduction to Downstream Process Development, Cambridge Innovation Institute.

If you want to learn more about downstream manufacturing processes, please join David Wood: 

Part 1: Introduction to Downstream Process Development – BASIC STRATEGIES (01/26/2021)

Part 2: Case Studies – Known Processes and Downstream Platforms (02/02/2021)

Part 3: Cutting-Edge Processes and Next-Generation Technologies (02/09/2021)

2020 Webinar Session Organized by GenScript

"A general capture and purification platform for tagless proteins based on a self-cleaving split-intein tag", by David W. Wood, December 2, 2020  at 2 p.m. EST.   

PEGS Europe Virtual

David Wood, Evaluating a New Technology in the Context of Historical Successes and Failures: A Case Study on Self- Cleaving Tags, PEGS Europe Virtual, Lisbon, Portugal, November 9-13, 2020.

The Bioprocessing Summit, 2020

David Wood presents vitually updates on intein research, Advances in Purification at CHI's Bioprocessing Summit, Boston, August 24-28th, 2020.

Learn more about biotechnology and bioprocessing:

Bioprocessing, Bioengineering and Process Chemistry in the Biopharmaceutical Industry: Using Chemistry and Bioengineering to Improve the Performance of Biologics, Gadamasetti K. and Kolodziej S. A. (Editors), 2024 Edition, Springer Nature (published online on November 24, 2024)

Highly selective split intein method for efficient separation and purification of recombinant therapeutic proteins from mammalian cell culture fluid

S. V. Prabhala, B. Marshall, J. Galiardi, Y. Fan, E. Creamer and D. W. Wood, Highly selective split intein method for efficient separation and purification of recombinant therapeutic proteins from mammalian cell culture fluid, Journal of Chromatography A, 2024 Vol. 1736,  465430. https://doi.org/10.1016/j.chroma.2024.465430

Prabhala S.V.; Wood D.W. A Scalable dual column cation exchange affinity chromatography based platform process for recombinant protein purification, Protein Expression and Purification, 2024, 217, 106442. https://doi.org/10.1016/j.pep.2024.106442. PMID: 38336119.

Prabhala S.V.; Mayone S.A.; Moody N.M.; Kanu C.B.; Wood D.W. A Convenient Self-Removing Affinity Tag Method for the Simple Purification of Tagless Recombinant Proteins, Current Protocols, 2023, 3 (10), e901. doi: 10.1002/cpz1.901. PMID: 37882966.

Prabhala, S.V.; Gierach, I.; Wood, D.W. The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent History. Frontiers in Molecular Biosciences, 2022, 9:857566. doi: 10.3389/fmolb.2022.857566.

Industry Innovators 2021-2022 Issue by BioProcess International Features the iCapTag, a New Product for Protein Purification

Gierach, I.; Wood, D. The iCapTag Protein Purification Platform Bridging Research and Manufacturing, BioProcess International, Industry Innovators 2021-2022, 2021, Vol. 19, Number 7-8, pp. 26-27. 

Remington, 2020

Learn more about the Biotechnology and Biopharmaceuticals Manufacturing: Protein drug production and formulation (Chapter 26th), Izabela Gierach, Jackelyn M. Galiardi, Brian Marshall and David W. Wood, The Science and Practice of Pharmacy, Remington, 23rd Edition, Elsevier, October, 2020.

Hardcover ISBN: 9780128200070

More about Remington Editions:

Remington Editions "The Science & Practice of Pharmacy" are well known as the most used, comprehensive textbooks and references on pharmaceutical sciences in the U.S. for the last 100 years. Remington's first edition was published by Joseph Prince Remington, a dean at the Philadelphia College of Pharmacy (know after substantial expansion as a private University of the Sciences in Philadelphia and the first pharmacy school in the U.S. since 1821). The University  is known for many alumni who became pioneers in healthcare-related innovations, drug discovery, and for building first pharmaceutical companies in the U.S. such as GSK (Silas M. Burroughs, class of 1877 and Henry S. Wellcome, class of 1874), Wyeth (acquired by Pfizer; John Wyeth, class of 1854), Eli Lilly (Eli Lilly, class of 1907 and Josiah K. Lilly, class of 1882), William R. Warner & Co. (acquired by Pfizer; William R. Warner, class of 1856), Rorer Pharmaceuticals (acquired by Sanofi; Gerald F. Rorer; class of 1931), McNeil Consumer Products Company (now McNeil Consumer Healthcare) and McNeil Pharmaceutical (now part of Janssen Pharmaceuticals, Inc.) led by Robert L. McNeil, Jr. (class of 1938) and his grandfather, Robert McNeil (class of 1876). 

American Pharmaceutical Review, 2019

Izabela Gierach and David Wood, Self-Cleaving Tags Based on Split Inteins: Increased Reliability Enabling Higher Throughput Applications, American Pharmaceutical Review, 2019, 22(1), 66-69.